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Aug 01, 2019 · The majority of acidic drugs have low steady-state distribution volumes (V ss) in the range of 0.1–0.3 l/kg (Grime et al., 2013) due to a combination of high plasma protein binding (PPB) and low tissue distribution (Smith et al., 2010) unless active hepatic uptake is a determining factor (Grover and Benet, 2009; Gardiner and Paine, 2011).