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The Australian Customer’s V947 Autosampler Vial Order is Completed
The Australian Customer’s V947 Autosampler Vial Order is Completed
American Customer Ordered 100,000 Boxes of 9-425 2ml HPLC Vials
American Customer Ordered 100,000 Boxes of 9-425 2ml HPLC Vials
5000-boxes-of-blue-screw-cap-10-425-hplc-vial-sent-to-singapore
5000-boxes-of-blue-screw-cap-10-425-hplc-vial-sent-to-singapore
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Glass forming: what the line controls before the vial exists
Glass forming: what the line controls before the vial exists
April 5, 2018
Glass forming: what the line controls before the vial exists
I once traced a 4.7% RSD drift across a 200-vial sequence to a single forming die on cavity 14 of a 40-cavity mold. The part measured 11.97 mm OD at the neck instead of 12.00 mm. The autosampler gripper compensated just enough to mask it for 170 injections, then a needle hit the cap at a 0.3 mm offset and bent. That is what a vial factory actually controls on the line: not the catalog spec, but the 40 or 64 or 96 individual cavities, the three or four molding parameters that drift per cavit...
USP chapter 621 is the only chapter that directly names the vial, and it
USP chapter 621 is the only chapter that directly names the vial, and it
April 5, 2018
USP chapter 621 is the only chapter that directly names the vial, and it
A stability-indicating method for a lyophilized peptide had passed validation in August, then failed system suitability in November. The same lot of mobile phase, the same column, the same reference standard. The only variable was a new case of 12×32 mm screw-top vials from a different supplier. Carryover jumped from 0.05% to 0.31%. The investigation took three days and ended at the vial. The USP chapters that govern that vial were never consulted during the supplier change, and that i...
What actually varies between vial lots
What actually varies between vial lots
April 5, 2018
What actually varies between vial lots
I have watched a validated method fail on a Monday morning because someone opened a new case of vials from a different lot. The chromatograms were not catastrophically wrong. They were just slightly worse: peak area RSD crept from 0.4% to 1.8%, one late-eluting peak grew a shoulder, and the autosampler started logging a few “no sample” errors on the first injection of each tray. Nothing in the method had changed. The vials had. Finding that took three days of instrument checks t...